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Great question! Business related expenses can be deducted if your wife's social media influencer activity is a business. The IRS generally defines a business as having a profit motive. There are other factors to consider like how much time is spent on the activity and if she relies on the income she receives for her livelihood. If it meets the IRS definition of a business, then business related expenses can be deducted against any income she receives. As long as your wife was considered active in her social media influencer business, generally losses can be offset against other sources of income.